Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

OBJECTIVE: 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic β-cells. It enhances interleukin 12 production by macrophages, and several of its p...

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Главные авторы: McDuffie, Marcia, Maybee, Nelly A., Keller, Susanna R., Stevens, Brian K., Garmey, James C., Morris, Margaret A., Kropf, Elizabeth, Rival, Claudia, Ma, Kaiwen, Carter, Jeffrey D., Tersey, Sarah A., Nunemaker, Craig S., Nadler, Jerry L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993320/
https://ncbi.nlm.nih.gov/pubmed/17940120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-0830
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