Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

OBJECTIVE: 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic β-cells. It enhances interleukin 12 production by macrophages, and several of its p...

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Hauptverfasser: McDuffie, Marcia, Maybee, Nelly A., Keller, Susanna R., Stevens, Brian K., Garmey, James C., Morris, Margaret A., Kropf, Elizabeth, Rival, Claudia, Ma, Kaiwen, Carter, Jeffrey D., Tersey, Sarah A., Nunemaker, Craig S., Nadler, Jerry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993320/
https://ncbi.nlm.nih.gov/pubmed/17940120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-0830
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