Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development

AIMS: Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion of the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mice leads to nearly 100 percent protection from T1D. In this study, we test the hypothe...

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Hauptverfasser: Green-Mitchell, Shamina M., Tersey, Sarah A., Cole, Banumathi K., Ma, Kaiwen, Kuhn, Norine S., Cunningham, Tina Duong, Maybee, Nelly A., Chakrabarti, Swarup K., McDuffie, Marcia, Taylor-Fishwick, David A., Mirmira, Raghavendra G., Nadler, Jerry L., Morris, Margaret A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578926/
https://ncbi.nlm.nih.gov/pubmed/23437231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056763
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