Bactericidal antibiotics promote oxidative damage and programmed cell death in sinonasal epithelial cells

BACKGROUND: Antibiotics are widely and heavily used in the treatment of chronic sinusitis. Bactericidal antibiotics can stimulate reactive oxygen species (ROS) formation, a pro-inflammatory response and cell death in cultured human sinonasal epithelial cells(SNECs). Sulforaphane is a potent stimulat...

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Bibliographic Details
Published in:Int Forum Allergy Rhinol
Main Authors: Kohanski, Michael A., Tharakan, Anuj, London, Nyall R., Lane, Andrew P., Ramanathan, Murugappan
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386800/
https://ncbi.nlm.nih.gov/pubmed/28117948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alr.21914
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