Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

The use of tumor-treating fields (TTFields) has revolutionized the treatment of recurrent and newly diagnosed glioblastoma (GBM). TTFields are low-intensity, intermediate frequency, alternating electric fields that are applied to tumor regions and cells using non-invasive arrays. The predominant mec...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Karanam, Narasimha Kumar, Srinivasan, Kalayarasan, Ding, Lianghao, Sishc, Brock, Saha, Debabrata, Story, Michael D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386539/
https://ncbi.nlm.nih.gov/pubmed/28358361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.136
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