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Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network

DNA double-strand breaks (DSBs) occur in response to both endogenous and exogenous genotoxic stress. Inappropriate repair of DSBs can lead to either loss of viability or to chromosomal alterations that increase the likelihood of cancer development. In strong support of this assertion, many cancer pr...

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Enregistré dans:
Détails bibliographiques
Auteur principal: Greenberg, Roger A.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692651/
https://ncbi.nlm.nih.gov/pubmed/18369654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00412-008-0154-8
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