Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the exquisite coordination of multiple signaling and repair factors. Here, we conducted a functional RNAi screen and identified BAP1 as a deubiquitinase required for efficient assembly of the homologous recombination...

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Hlavní autoři: Yu, Helen, Pak, Helen, Hammond-Martel, Ian, Ghram, Mehdi, Rodrigue, Amélie, Daou, Salima, Barbour, Haithem, Corbeil, Luc, Hébert, Josée, Drobetsky, Elliot, Masson, Jean Yves, Di Noia, Javier M., Affar, El Bachir
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890818/
https://ncbi.nlm.nih.gov/pubmed/24347639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309085110
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