Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death

Upregulation of Smad7, an inhibitor of transforming growth factor-β1 (TGF-β1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: De Simone, Veronica, Bevivino, Gerolamo, Sedda, Silvia, Izzo, Roberta, Laudisi, Federica, Dinallo, Vincenzo, Franzè, Eleonora, Colantoni, Alfredo, Ortenzi, Angela, Salvatori, Silvia, Rossi, Piero, Sica, Giuseppe S, Fantini, Massimo C, Stolfi, Carmine, Monteleone, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386514/
https://ncbi.nlm.nih.gov/pubmed/28300830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.103
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