Reciprocal Regulation Between Smad7 and Sirt1 in the Gut

In inflammatory bowel disease (IBD) mucosa, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine transforming growth factor-β1, due to post-transcriptional mechanisms that enhance Smad7 acetylation status thus preventing ubiquitination-mediated proteosomal degrad...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Sedda, Silvia, Franzè, Eleonora, Bevivino, Gerolamo, Di Giovangiulio, Martina, Rizzo, Angelamaria, Colantoni, Alfredo, Ortenzi, Angela, Grasso, Enrico, Giannelli, Mario, Sica, Giuseppe S., Fantini, Massimo Claudio, Monteleone, Giovanni
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097015/
https://ncbi.nlm.nih.gov/pubmed/30147698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01854
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