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Reciprocal Regulation Between Smad7 and Sirt1 in the Gut
In inflammatory bowel disease (IBD) mucosa, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine transforming growth factor-β1, due to post-transcriptional mechanisms that enhance Smad7 acetylation status thus preventing ubiquitination-mediated proteosomal degrad...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097015/ https://ncbi.nlm.nih.gov/pubmed/30147698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01854 |
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