Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death

Upregulation of Smad7, an inhibitor of transforming growth factor-β1 (TGF-β1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: De Simone, Veronica, Bevivino, Gerolamo, Sedda, Silvia, Izzo, Roberta, Laudisi, Federica, Dinallo, Vincenzo, Franzè, Eleonora, Colantoni, Alfredo, Ortenzi, Angela, Salvatori, Silvia, Rossi, Piero, Sica, Giuseppe S, Fantini, Massimo C, Stolfi, Carmine, Monteleone, Giovanni
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386514/
https://ncbi.nlm.nih.gov/pubmed/28300830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.103
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg