Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells

Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an attractive therapeutic target in CRC, conv...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Laudisi, Federica, Cherubini, Fabio, Di Grazia, Antonio, Dinallo, Vincenzo, Di Fusco, Davide, Franzè, Eleonora, Ortenzi, Angela, Salvatori, Illari, Scaricamazza, Silvia, Monteleone, Ivan, Sakamoto, Naoya, Monteleone, Giovanni, Stolfi, Carmine
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763778/
https://ncbi.nlm.nih.gov/pubmed/31361391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12552
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