DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis

The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as Navitoclax and Venetoclax, in treating BCL-2-dependent haematological malignancies. However, most solid tumours depend on MCL-1 for survival, which is highly amplified in multipl...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Milani, Mateus, Byrne, Dominic P, Greaves, Georgia, Butterworth, Michael, Cohen, Gerald M, Eyers, Patrick A, Varadarajan, Shankar
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386385/
https://ncbi.nlm.nih.gov/pubmed/28079887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.485
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