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DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Maintenance of mitochondrial integrity is critical for normal cellular homoeostasis. Most cells respond to stress stimuli and undergo apoptosis by perturbing mitochondrial structure and function to release proteins, such as cytochrome c, which are essential for the execution of the intrinsic apoptot...

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Détails bibliographiques
Publié dans:Cell Death Discov
Auteurs principaux: Milani, Mateus, Beckett, Alison J., Al-Zebeeby, Aoula, Luo, Xu, Prior, Ian A., Cohen, Gerald M., Varadarajan, Shankar
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637195/
https://ncbi.nlm.nih.gov/pubmed/31341643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0199-x
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