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DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as Navitoclax and Venetoclax, in treating BCL-2-dependent haematological malignancies. However, most solid tumours depend on MCL-1 for survival, which is highly amplified in multipl...
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| Publicado en: | Cell Death Dis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5386385/ https://ncbi.nlm.nih.gov/pubmed/28079887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.485 |
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