Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a ma...

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Опубликовано в: :Cell Death Dis
Главные авторы: Ugun-Klusek, Aslihan, Tatham, Michael H, Elkharaz, Jamal, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mohamed, Hala, Paine, Simon M L, Anderson, Glen, John Mayer, R, Lowe, James, Ellen Billett, E, Bedford, Lynn
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386360/
https://ncbi.nlm.nih.gov/pubmed/28055010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.443
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