Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in cells. These pathways are interdependent, and dysfunction in either pathway causes accumulation of ubiquitin-positive aggregates, a hallmark of human pathological conditions. To elucidate in vivo compensatory a...

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Detalhes bibliográficos
Main Authors: Kageyama, Shun, Sou, Yu-shin, Uemura, Takefumi, Kametaka, Satoshi, Saito, Tetsuya, Ishimura, Ryosuke, Kouno, Tsuguka, Bedford, Lynn, Mayer, R. John, Lee, Myung-Shik, Yamamoto, Masayuki, Waguri, Satoshi, Tanaka, Keiji, Komatsu, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155663/
https://ncbi.nlm.nih.gov/pubmed/25049227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580357
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