Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-Synuclein

Parkinson’s disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurones and the formation of Lewy bodies (LB) in a proportion of the remaining neurones. α-synuclein is the main component of LB, but the pathological mechanisms that lead...

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Main Authors: Paine, Simon M. L., Anderson, Glenn, Bedford, Karen, Lawler, Karen, Mayer, R. John, Lowe, James, Bedford, Lynn
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559752/
https://ncbi.nlm.nih.gov/pubmed/23382946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054711
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