Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus

Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack of expression of cell cycle inhibitors, which ultimate...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: De Jaime-Soguero, Anchel, Aulicino, Francesco, Ertaylan, Gokhan, Griego, Anna, Cerrato, Aniello, Tallam, Aravind, del Sol, Antonio, Cosma, Maria Pia, Lluis, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386305/
https://ncbi.nlm.nih.gov/pubmed/28346462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006682
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