A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma

Although signaling from PI3K and AKT to mTOR is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mTORC1 compared to mTOR kinase inhibitors (TORKi)...

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Publicat a:Cancer Cell
Autors principals: Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cavanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386178/
https://ncbi.nlm.nih.gov/pubmed/28292440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.014
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