A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma

Although signaling from PI3K and AKT to mTOR is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mTORC1 compared to mTOR kinase inhibitors (TORKi)...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cavanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386178/
https://ncbi.nlm.nih.gov/pubmed/28292440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.014
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