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mTOR function and therapeutic targeting in breast cancer

The mTOR pathway was discovered in the late 1970s after the compound and natural inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus. mTOR is serine/threonine kinase belonging to the phosphoinositide 3-kinase related kinase (PIKK) family. It forms two distinct com...

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Библиографические подробности
Опубликовано в: :Am J Cancer Res
Главные авторы: Hare, Stephen H, Harvey, Amanda J
Формат: Artigo
Язык:Inglês
Опубликовано: e-Century Publishing Corporation 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385631/
https://ncbi.nlm.nih.gov/pubmed/28400999
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