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Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of protein translation, cell growth and metabolism. The mTOR protein forms two distinct multi-subunit complexes: mTORC1 and mTORC2. The mTORC1 complex is activated by diverse stimuli, such as growth factors, nutrients...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128044/ https://ncbi.nlm.nih.gov/pubmed/24780124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12749 |
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