Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

BACKGROUND: Activation of the PI3K/mTOR and Hedgehog (Hh) signalling pathways occurs frequently in biliary tract cancer (BTC). Crosstalk between these pathways occurs in other gastrointestinal cancers. The respective signalling inhibitors rapamycin and vismodegib may inhibit BTC synergistically and...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Zuo, M, Rashid, A, Churi, C, Vauthey, J-N, Chang, P, Li, Y, Hung, M-C, Li, D, Javle, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366884/
https://ncbi.nlm.nih.gov/pubmed/25742482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.625
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