Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

BACKGROUND: Activation of the PI3K/mTOR and Hedgehog (Hh) signalling pathways occurs frequently in biliary tract cancer (BTC). Crosstalk between these pathways occurs in other gastrointestinal cancers. The respective signalling inhibitors rapamycin and vismodegib may inhibit BTC synergistically and...

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Publicat a:Br J Cancer
Autors principals: Zuo, M, Rashid, A, Churi, C, Vauthey, J-N, Chang, P, Li, Y, Hung, M-C, Li, D, Javle, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366884/
https://ncbi.nlm.nih.gov/pubmed/25742482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.625
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