Polynitroxylated Pegylated Hemoglobin—A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation

Resuscitation with polynitroxylated pegylated hemoglobin (PNPH), a pegylated bovine hemoglobin decorated with nitroxides, eliminated the need for fluid administration, reduced intracranial pressure (ICP) and brain edema, and produced neuroprotection in vitro and in vivo versus Lactated Ringer's...

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Pubblicato in:J Neurotrauma
Autori principali: Brockman, Erik C., Jackson, Travis C., Dixon, C. Edward, Bayɪr, Hülya, Clark, Robert S. B., Vagni, Vincent, Feldman, Keri, Byrd, Catherine, Ma, Li, Hsia, Carleton, Kochanek, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2017
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385578/
https://ncbi.nlm.nih.gov/pubmed/27869558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2016.4656
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