Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice

Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polyethylene glycol moieties, showed neuroprotection vs. lactated Ringer's (LR) in experimental traumatic brain injury plus hemorrhagic shock (TBI+HS). Hypothesis: Resuscitation with PNPH will reduce...

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Autori principali: Brockman, Erik C, Bayır, Hülya, Blasiole, Brian, Shein, Steven L, Fink, Ericka L, Dixon, CEdward, Clark, Robert SB, Vagni, Vincent A, Ma, Li, Hsia, Carleton JC, Tisherman, Samuel A, Kochanek, Patrick M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764379/
https://ncbi.nlm.nih.gov/pubmed/23801241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.104
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