Polynitroxylated Pegylated Hemoglobin: A Novel Neuroprotective Hemoglobin for Acute Volume-Limited Fluid Resuscitation after Combined Traumatic Brain Injury and Hemorrhagic Hypotension in Mice

OBJECTIVE: Resuscitation of hemorrhagic hypotension after traumatic brain injury (TBI) is challenging. A hemoglobin (Hb)-based oxygen carrier (HBOC) may offer advantages. The novel therapeutic HBOC, polynitroxylated pegylated Hb (PNPH) may represent a neuroprotective HBOC for TBI resuscitation. HYPO...

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Main Authors: Shellington, David K., Du, Lina, Wu, Xianren, Exo, Jennifer, Vagni, Vincent, Ma, Li, Janesko-Feldman, Keri, Clark, Robert S.B., Bayır, Hülya, Dixon, C. Edward, Jenkins, Larry W., Hsia, Carleton J.C., Kochanek, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425360/
https://ncbi.nlm.nih.gov/pubmed/21169820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318206b1fa
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