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Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

BACKGROUND: Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and permits it...

詳細記述

保存先:
書誌詳細
出版年:BMC Neurosci
主要な著者: Seno, Soichiro, Wang, Jun, Cao, Suyi, Saraswati, Manda, Park, Sharon, Simoni, Jan, Ma, Li, Soltys, Bohdan, Hsia, Carleton J. C., Koehler, Raymond C., Robertson, Courtney L.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222507/
https://ncbi.nlm.nih.gov/pubmed/32404052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-020-00571-7
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