Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics

Superoxide is produced as a result of normal energy metabolism within the mitochondria and is scavenged by the mitochondrial form of superoxide dismutase (sod2). Mice with inactivated SOD2 (sod2 nullizygous mice) die prematurely, exhibiting several metabolic and mitochondrial defects and severe tiss...

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Pubblicato in:J Neurosci
Autori principali: Melov, Simon, Doctrow, Susan R., Schneider, Julie A., Haberson, Joanna, Patel, Manisha, Coskun, Pinar E., Huffman, Karl, Wallace, Douglas C., Malfroy, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762800/
https://ncbi.nlm.nih.gov/pubmed/11606622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-21-08348.2001
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