CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma

AIM: To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS: Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which...

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Bibliographische Detailangaben
Veröffentlicht in:World J Gastroenterol
Hauptverfasser: Wu, Jing-Hua, Guo, Jia-Pei, Shi, Jun, Wang, Hui, Li, Lei-Lei, Guo, Bin, Liu, Dian-Xing, Cao, Qing, Yuan, Zhi-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Baishideng Publishing Group Inc 2017
Schlagworte:
Basic Study
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385397/
https://ncbi.nlm.nih.gov/pubmed/28428710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i13.2308
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