Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway

Bromodomain and Extra-Terminal Domain (BET) inhibitors, such as JQ1 have emerged as novel drug candidates and are being enthusiastically pursued in clinical trials for the treatment of cancer. However, many solid cancers are resistance to BET inhibitors. To explore methods for improving the therapeu...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Hua-Peng, Li, Gong-Quan, Guo, Wen-Zhi, Chen, Guang-Hui, Tang, Hong-Wei, Yan, Bing, Li, Jie, Zhang, Jia-Kai, Wen, Pei-Hao, Wang, Zhi-Hui, Lv, Jian-Feng, Zhang, Shui-Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739777/
https://ncbi.nlm.nih.gov/pubmed/29290992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21880
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