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Enthalpy–entropy compensation: the role of solvation
Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional expl...
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| Udgivet i: | Eur Biophys J |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Berlin Heidelberg
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5384952/ https://ncbi.nlm.nih.gov/pubmed/27796417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-016-1182-6 |
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