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Enthalpy–entropy compensation: the role of solvation

Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional expl...

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Pubblicato in:Eur Biophys J
Autori principali: Dragan, Anatoliy I., Read, Christopher M., Crane-Robinson, Colyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384952/
https://ncbi.nlm.nih.gov/pubmed/27796417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-016-1182-6
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