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Enthalpy–entropy compensation: the role of solvation

Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional expl...

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Bibliografski detalji
Izdano u:Eur Biophys J
Glavni autori: Dragan, Anatoliy I., Read, Christopher M., Crane-Robinson, Colyn
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384952/
https://ncbi.nlm.nih.gov/pubmed/27796417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-016-1182-6
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