Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells

Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7’s precise exocytotic actions in β-cells remain unknown. We show that Syt-7 is abundant in h...

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Publicado en:Diabetes
Autores principales: Dolai, Subhankar, Xie, Li, Zhu, Dan, Liang, Tao, Qin, Tairan, Xie, Huanli, Kang, Youhou, Chapman, Edwin R., Gaisano, Herbert Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2016
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384637/
https://ncbi.nlm.nih.gov/pubmed/27207520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1436
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