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Inhibition of EZH2 degradation as a novel approach to overcome drug resistance in acute myeloid leukemia
The polycomb protein enhancer of zeste homolog 2 (EZH2) may have a dual role in cancer pathogenesis acting as an oncogene or as a tumor suppressor depending on the cancer type. We recently demonstrated that proteasomal degradation of EZH2 resulting from cyclin-dependent kinase 1 (CDK1)-induced phosp...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5383362/ https://ncbi.nlm.nih.gov/pubmed/28401191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1291396 |
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