Inhibition of c-Myc Overcomes Cytotoxic Drug Resistance in Acute Myeloid Leukemia Cells by Promoting Differentiation

Nowadays, drug resistance still represents a major obstacle to successful acute myeloid leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we found that high expression of c-Myc was one of the cytogenetic characteristics in the drug-resistant leukemic cells. c-Myc o...

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Detalhes bibliográficos
Main Authors: Pan, Xiao-Na, Chen, Jia-Jie, Wang, Le-Xun, Xiao, Ruo-Zhi, Liu, Ling-Ling, Fang, Zhi-Gang, Liu, Quentin, Long, Zi-Jie, Lin, Dong-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134294/
https://ncbi.nlm.nih.gov/pubmed/25127121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105381
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