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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells

BACKGROUND/AIMS: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of patients receiving nilotinib developed diabetes. Metformin is a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Korean J Intern Med
Prif Awduron: Na, Yoo Jin, Yu, Eun Sang, Kim, Dae Sik, Lee, Dae-Hee, Oh, Sang Cheul, Choi, Chul Won
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Korean Association of Internal Medicine 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009173/
https://ncbi.nlm.nih.gov/pubmed/32241082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.2019.336
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