Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model

The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random mutations and recombination events. The resulting diversity of Env variants circulating in the population and their continuing diversification process limit the efficacy of AIDS vaccines. We examined the historic ch...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: DeLeon, Orlando, Hodis, Hagit, O’Malley, Yunxia, Johnson, Jacklyn, Salimi, Hamid, Zhai, Yinjie, Winter, Elizabeth, Remec, Claire, Eichelberger, Noah, Van Cleave, Brandon, Puliadi, Ramya, Harrington, Robert D., Stapleton, Jack T., Haim, Hillel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383018/
https://ncbi.nlm.nih.gov/pubmed/28384158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001549
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