The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization

The envelope glycoproteins (Envs) of HIV-1 are embedded in the cholesterol-rich lipid membrane of the virus. Chemical depletion of cholesterol from HIV-1 particles inactivates their infectivity. We observed that diverse HIV-1 strains exhibit a range of sensitivities to such treatment. Differences in...

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Foilsithe in:J Biol Chem
Main Authors: Salimi, Hamid, Johnson, Jacklyn, Flores, Manuel G., Zhang, Michael S., O'Malley, Yunxia, Houtman, Jon C., Schlievert, Patrick M., Haim, Hillel
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Microbiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956520/
https://ncbi.nlm.nih.gov/pubmed/31757809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009481
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