Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model

The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random mutations and recombination events. The resulting diversity of Env variants circulating in the population and their continuing diversification process limit the efficacy of AIDS vaccines. We examined the historic ch...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: DeLeon, Orlando, Hodis, Hagit, O’Malley, Yunxia, Johnson, Jacklyn, Salimi, Hamid, Zhai, Yinjie, Winter, Elizabeth, Remec, Claire, Eichelberger, Noah, Van Cleave, Brandon, Puliadi, Ramya, Harrington, Robert D., Stapleton, Jack T., Haim, Hillel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383018/
https://ncbi.nlm.nih.gov/pubmed/28384158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001549
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