Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

The peptide nociceptin/orphanin FQ (N/OFQ) and the N/OFQ receptor (NOP) constitute a neuropeptidergic system that modulates various biological functions and is currently targeted for the generation of innovative drugs. In the present study dimeric NOP receptor ligands with spacers of different lengt...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Pacifico, Salvatore, Carotenuto, Alfonso, Brancaccio, Diego, Novellino, Ettore, Marzola, Erika, Ferrari, Federica, Cerlesi, Maria Camilla, Trapella, Claudio, Preti, Delia, Salvadori, Severo, Calò, Girolamo, Guerrini, Remo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382891/
https://ncbi.nlm.nih.gov/pubmed/28383520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45817
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