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Crystal structure of the MOP flippase MurJ in an inward-facing conformation
Peptidoglycan (PG) protects bacteria from osmotic lysis, and its biogenesis is a key antibiotic target. A central step in PG biosynthesis is to flip the lipid-linked PG precursor lipid II across the cytoplasmic membrane for subsequent incorporation into peptidoglycan. MurJ, part of the multidrug/oli...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5382020/ https://ncbi.nlm.nih.gov/pubmed/28024149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3346 |
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