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Detection of transport intermediates in the peptidoglycan flippase MurJ identifies residues essential for conformational cycling
Bacterial cell wall synthesis is an essential process in bacteria and one of the best targets for antibiotics. A critical step on this pathway is the export of the lipid-linked cell wall monomer, Lipid II, by its transporter MurJ. The mechanism by which MurJ mediates the transbilayer movement of Lip...
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| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192318/ https://ncbi.nlm.nih.gov/pubmed/32129990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b12185 |
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