Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells

The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular, the capacity to cross-present exogenous antigens...

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Udgivet i:Cell Mol Immunol
Main Authors: Fehres, Cynthia M, Duinkerken, Sanne, Bruijns, Sven CM, Kalay, Hakan, van Vliet, Sandra J, Ambrosini, Martino, de Gruijl, Tanja D, Unger, Wendy WJ, Garcia-Vallejo, Juan J, van Kooyk, Yvette
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380941/
https://ncbi.nlm.nih.gov/pubmed/26456691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.87
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