HIV-1 Capsid Function is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD

HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo motions spanning many deca...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Zhang, Huilan, Hou, Guangjin, Lu, Manman, Ahn, Jinwoo, Byeon, In-Ja L., Langmead, Christopher J., Perilla, Juan R., Hung, Ivan, Gor’kov, Peter L., Gan, Zhehong, Brey, William W., Case, David A., Schulten, Klaus, Gronenborn, Angela M., Polenova, Tatyana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380593/
https://ncbi.nlm.nih.gov/pubmed/27701859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08744
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