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HIV-1 Capsid Function is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD

HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo motions spanning many deca...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Am Chem Soc
Main Authors: Zhang, Huilan, Hou, Guangjin, Lu, Manman, Ahn, Jinwoo, Byeon, In-Ja L., Langmead, Christopher J., Perilla, Juan R., Hung, Ivan, Gor’kov, Peter L., Gan, Zhehong, Brey, William W., Case, David A., Schulten, Klaus, Gronenborn, Angela M., Polenova, Tatyana
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380593/
https://ncbi.nlm.nih.gov/pubmed/27701859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08744
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