Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR

HIV-1 capsid plays multiple key roles in viral replication, and inhibition of capsid assembly is an attractive target for therapeutic intervention. Here, we report the atomic-resolution structure of the capsid protein (CA) tubes, determined by magic-angle-spinning NMR and data-guided molecular dynam...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Struct Mol Biol
Prif Awduron: Lu, Manman, Russell, Ryan W., Bryer, Alex, Quinn, Caitlin M., Hou, Guangjin, Zhang, Huilan, Schwieters, Charles D., Perilla, Juan R., Gronenborn, Angela M., Polenova, Tatyana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490828/
https://ncbi.nlm.nih.gov/pubmed/32901160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0489-2
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