The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial. In this study, we demonstrate that ablation of Foxo1 af...

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Vydáno v:J Exp Med
Hlavní autoři: Inoue, Takeshi, Shinnakasu, Ryo, Ise, Wataru, Kawai, Chie, Egawa, Takeshi, Kurosaki, Tomohiro
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379976/
https://ncbi.nlm.nih.gov/pubmed/28351982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161263
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