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Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal
A still unanswered question is what drives the small fraction of activated germinal center (GC) B cells to become long-lived quiescent memory B cells. We found here that a small population of GC-derived CD38(int)Bcl6(hi/int)Efnb1(+) cells with lower mTORC1 activity favored the memory B cell fate. Co...
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| Publicat a: | J Exp Med |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Rockefeller University Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7555411/ https://ncbi.nlm.nih.gov/pubmed/33045065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200866 |
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