Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

A still unanswered question is what drives the small fraction of activated germinal center (GC) B cells to become long-lived quiescent memory B cells. We found here that a small population of GC-derived CD38(int)Bcl6(hi/int)Efnb1(+) cells with lower mTORC1 activity favored the memory B cell fate. Co...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Inoue, Takeshi, Shinnakasu, Ryo, Kawai, Chie, Ise, Wataru, Kawakami, Eiryo, Sax, Nicolas, Oki, Toshihiko, Kitamura, Toshio, Yamashita, Kazuo, Fukuyama, Hidehiro, Kurosaki, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555411/
https://ncbi.nlm.nih.gov/pubmed/33045065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200866
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